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  1. Stem Cell/Wnt
  2. Notch

JI051 

目录号: HY-117113
Data Sheet产品使用指南

JI051 是一种 Hes1-PHB2 相互作用稳定剂,能够与癌症相关蛋白伴侣 prohibitin 2 (PHB2) 相互作用,通过抑制 Notch 下游效应基因 Hes1 来诱导细胞周期停滞。具有抗肿瘤作用。

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JI051 Chemical Structure

JI051 Chemical Structure

CAS No. : 2234281-75-3

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100 mg ¥35000 Get quote

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Description

JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].

In Vitro

JI051 causes G2/M cell-cycle arrest[1].
JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1].

Cell Proliferation Assay[1]

Cell Line:HEK293 cells
Concentration:0.1-10 µM
Incubation Time:24 hours
Result:Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.
References
  • [1].Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.

Molecular Weight

364.44

Formula

C₂₂H₂₄N₂O₃

CAS No.

2234281-75-3

SMILES

O=C(NCCC1=CC=CC=C1OCC)/C=C/C2=CNC3=C2C=CC=C3OC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Data Sheet (92 KB)产品使用指南 (1213 KB)
  • [1].Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.

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The molarity calculator equation

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The dilution calculator equation

Concentration(start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration(start)×Volume(start)=Concentration(final)×Volume(final)
×=×
C1 V1 C2 V2

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产品名称:
JI051
目录号:
HY-117113
需求量:

JI051

Cat. No.: HY-117113